Hosted by the Pharmacogenomics SIG, in collaboration with the Minority Faculty SIG and the Healthcare Disparities and Cultural Competency SIG.
Pharmacogenomics involves the association of genetic variation with therapeutic outcomes. The human genome, however, is only one part of the puzzle and understanding the complexities on how the genomic variation is reflected in gene expression transcript, protein variation and the genetics of host-microbe interactions help to explain the variations incompletely captured by the genome alone. This webinar will introduce the concept of multi-omics approaches to understanding their effects on cardiovascular drug therapy, particularly in admixed and underrepresented populations. This webinar will cover the role of epigenomics, transcriptomics, proteomics, metabolomics, and the microbiome in the response to cardiovascular (CV)drugs.
The seminar will be divided in four sections (not including Introduction of speakers):
- Introduction to Multi-Omics Approaches; Proteomics and Transcriptomic studies for CV drugs in Latinx (15 min.), Drs. Jorge Duconge/Bianca Torres-Hernandez
- Epigenomics and Transcriptomic studies for CV drugs in African Americans (15 min.), Dr. Minoli Perera
- Microbiome/ Metabolomic studies for CV drugs (15 min.), Dr. Sony Tuteja
- Questions from the audience (5 min.)
Objectives:
- Define the terms: multi-omics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics.
- Describe examples of studies in progress to apply the proteomics and transcriptomics to cardiovascular pharmacotherapy in Latinx populations.
- Explain how epigenomics compliments transcriptomics and genomics and how these relate to differences in response to cardiovascular drugs in African American populations.
- Discuss the relationship between the gut microbiome, metabolomics, cardiovascular disease, and response to cardiovascular medications.
- Discuss the value of multi-omics approaches in augmenting precision medicine, particularly within the context of healthcare disparate populations.
Moderator:
Amy-Joan L. Ham, PhD
Associate Professor of Pharmaceuticals, Social and Administrative Sciences
College of Pharmacy and Health Sciences
Belmont University
Nashville, TN 37212
Speakers:
Jorge Duconge, PhD, MSc, BS Pharm
Professor & Assistant Dean for Research and Graduate Programs
University of Puerto Rico School of Pharmacy
San Juan, PR 00936-5067
Bianca A. Torres-Hernandez. PhD, MSc
Assistant Professor
Department of Pharmaceutical Sciences
University of Puerto Rico School of Pharmacy
San Juan, PR 00936-5067
Carolina Clark
Ph.D. Candidate
Department of Pharmacology
Northwestern University
Sony Tuteja, PharmD, MS, BCPS, FAHA
Research Assistant Professor of Medicine
Assistant Director, Pharmacogenomics
Penn Center for Genomic Medicine
University of Pennsylvania Perelman School of Medicine